Endocrine Abstracts

We recently generated a transgenic reporter mouse, ERE-Luc, to study ER transcriptional activity in pathophysiological states. In this model, luciferase synthesis is strictly associated with transcriptional activity of both ERα and ERβ, independent from the activity of receptors related to ERs. This enables to apply non-invasive imaging technologies to visualize ERs transcriptional activity in vivo, allowing to follow ERs activity in time in several organs in ...

We recently generated a transgenic reporter mouse, named ERE-Luc, to study the transcriptional activity of estrogen receptors (ERs) in patho-physiological states and showed that in this model system the synthesis of luciferase is strictly associated with an augmented transcriptional activity of both ERα and ERβ receptors but is independent from the activity of receptors related to ERs. Studies on ER activity in sexually mature, adult female mice showed that in cyclin...

A Maggi, Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, Milan, Italy Abstract Professor Adriana Maggi’s career has been devoted to the study of the activities of estrogens, initially in the central nervous system and, more recently, in other non-reproductive organs with the aim to understand the physiological importance of this hormone beyond the control of reproductiv...

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Observational studies have consistently shown a relationship between low testosterone (T) and a higher cardiovascular (CV) risk profile. However, it is still obscure whether reduced T levels in the elderly play a direct pathogenetic role in the stratification of CV risk, or if CV diseases (CVD) and low T are concomitant conditions, both associated with the aging process. Much evidence supports both of these possibilities. In the meanwhile, recent reports in the scientific and ...

Testosterone is the main male hormone controlling sexual and reproductive functions. Testosterone deficiency is associated with male hypogonadism, a syndromic condition that encompasses the well-recognised sexual and reproductive failure. Male hypogonadism has been, in fact, recently associated to an increased cardiovascular and metabolic risk (metabolic syndrome), most probably because testosterone deficiency is a stigmata of visceral adiposity. A stepwise reduction in testos...

Erectile dysfunction (ED) is a multidimensional disorder characterized by the inability to have successful intercourse with negative consequences in personal self-esteem and in couple relationship. Organic, relational and intrapsychic problems always concur in determining the erectile problem, although in different combination according to the patient characteristics, including age. Fifteen years ago, we have developed and validated a structured interview to identify and quant...

Background: Low testosterone (T) is frequent in men with chronical illnesses. The clinical features of T deficiency (TD) overlap with those of chronic diseases. The aim of this study is to evaluate the relative contribution of chronic disease score (CDS) and low T to the presence of TD symptoms.Methods: A consecutive series of 3862 men (aged 52.1±13.1 years) consulting for sexual dysfunction was studied. Several clinical and biochemical parameters w...

Introduction: Tadalafil 5 mg once daily (T5od) has been recently approved by the Food and Drug Administration for the treatment of lower urinary tract symptoms (LUTS), along with erectile dysfunction (ED). Recent pooled data analyses demonstrated that T5od–International Prostate Symptom Score related improvements were significant regardless of confounders. In addition, PDE5 inhibitors exert a positive effect on ejaculatory latency. We assessed the clinical outcome of 30 d...

Introduction: Secondary hypogonadism (sHG) is the most common form of hypogonadism. sHG can arise from any dysregulation of hypothalamic-pituitary (HP) axis due to functional or organic disorders. HP organic disorders are often diagnosed using pituitary magnetic resonance imaging (MRI). However, MRI is an expensive and not widespread exam and it cannot be routinely offered to all sHG patient. The Endocrine Society guidelines suggest MRI scan in sHG men with total testosterone ...